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Fat as a sensor of a worst inflammatory environment


Principal Investigator: Carolina Serena Perelló, PhD



Crosstalk between immune response and fuel storage mishandling. Immune function of adipose tissue is evolutionary preserved throughout species being now considered not only as a fuel storage organ but also with important functions, both in metabolic and immune responses in front homeostasis mishandling. Several chronic inflammatory diseases share adipose tissue derangements with important differences in the final expressed phenotype. In this line, new players such as microbial antigens or the innate capacity of hADSC hosted in adipose tissue, fighting against immune insults, are changing the view of adipose cell biology. We have focused our research in the events that are mediated by adipose tissue in the setting of Crohn disease and obesity, linking microbioma and immune/metabolic properties of hADSC.



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