Insulin resistance and Type-2 Diabetes (T2D) are direct consequences of obesity, causing a major public health problem and adipose tissue is one of the master keys in the insulin-resistance process associated to T2D. There is no unique major determinant in the reliability of the adipose tissue dysfunction in the setting of obesity, insulin-resistance and T2D and several components might contribute to the metabolic disturbances observed in these pathological situations. The central hypothesis of our group is based on the adipose tissue dysfunction as a key component in the development of obesity-associated metabolic disorders and not only a consequence of these pathologies.
Currently, we are focused in the following issues:
a) Role of adipose-derived stem cells (ASCs) in adipose tissue plasticity.
b) Adipose tissue as the nexus joining metabolism and immunity.
c) Inflammation and adipose tissue microbial signature.
d) Metabolic derangements in Gestational Diabetes: implications for placental metabolism and nutrient handling
e) Seeking new molecular links between obesity and cancer.
f) Biomarkers of subclinical atherosclerosis in Type 1 Diabetes.
To address these challenges, we combine basic and clinical research to integrate the knowhow of both areas and achieve results with a high level of translationality.All our efforts are focused on providing new clues to delineate the pathogenic basis underlying obesity and associated metabolic disorders, which ultimately may help to identify new targets for the treatment of these pathologies.